Patent · US Expired

1-ethyl-6-fluoro-1,4-dihydro- 7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and antibacterial use thereof

US4698350A · kind A · utility

5Cited by

6References

5Claims

0Family size

Assignee

Sterling Drug, Inc. · US

Inventors

Sol J. Daum · Albany, US
George Y. Lesher · Rockville Centre, US

Key dates

Filing date	Sep 17, 1984
Grant date	Oct 6, 1987
Priority date	—
Expiry date	Sep 17, 2004

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D213/26
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

1-Ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinoline carboxylic acid (Win 52,522) or salt thereof, a highly potent antibacterial agent, is prepared by nitrating the corresponding 6-desfluoro compound (Win 35,439) to produce the corresponding 6-nitro compound, reducing the latter compound to produce the corresponding 6-amino compound and converting the 6-amino via its diazonium salt to said 6-fluoro compound (Win 52,522). Comparative in vitro and in vivo antibacterial test data are provided to demonstrate the uniqueness of Win 52,522 as a highly potent antibacterial agent having a broad spectrum of antimicrobial activity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.