Tumoricidal methotrexate-antibody conjugate
US4699784A · kind A · utility
374Cited by
4References
12Claims
0Family size
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Key dates
| Filing date | Feb 25, 1986 |
| Grant date | Oct 13, 1987 |
| Priority date | — |
| Expiry date | Feb 25, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/809
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A conjugate of methotrexate to an antibody is prepared by loading methotrexate onto an aminodextran, then specifically conjugating the polymer carrier to the carbohydrate portion of an antitumor antibody, using a reduced Schiff base linkage. The conjugate is useful for tumor targeted therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.