Preparation of .alpha.,.alpha.-dihaloalkyl boronic esters
US4701545A · kind A · utility
6Cited by
1References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 12, 1986 |
| Grant date | Oct 20, 1987 |
| Priority date | — |
| Expiry date | Feb 12, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/025
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Esters of .alpha.,.alpha.-haloalkyl boronic acids are prepared by the addition of an alkali metal dialkylamide, or some other equivalent sterically hindered base to a mixture of a 1,1-dihaloalkane and a trialkyl borate in an organic solvent at a temperature between about -78.degree. C. and +25.degree. C. In one embodiment, diisopropyl (dichloromethyl)borate is formed by the addition of lithium diisopropylamide to a mixture of dichloromethane and triisopropyl borate in the presence of tetrahydrofuran as the solvent medium at a temperature between about -10.degree. C. and +10.degree. C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.