Method for the purification of LPF-HA
US4704274A · kind A · utility
23Cited by
3References
8Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 26, 1984 |
| Grant date | Nov 3, 1987 |
| Priority date | — |
| Expiry date | Oct 26, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/822
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for producing highly pure LPF-HA (Leucocytosis-promoting Factor agglutinin) from culture media of Bordetella pertussis in a high yield by an affinity chromatography using a denatured ceruloplasmin as a ligand. The LPF-HA obtained by this invention is highly pure and does not contain almost endotoxin of B. pertussis and is useful for the preparation of various reagents utilizing the physiological activities, a medicine for treating diabetes, and a pertussis vaccine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.