Transdermal therapeutic system having improved delivery characteristics
US4704282A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 29, 1984 |
| Grant date | Nov 3, 1987 |
| Priority date | — |
| Expiry date | Jun 29, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S424/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A transdermal therapeutic system using a subsaturated matrix is provided having improved approved release characteristics. Reinforcing means preferably in the form of a fabric are embedded in the upper surface of the subsaturated matrix. At least a portion of the reinforcing means is selected such that the active agent to be delivered to the skin has a solubility, C.sub.r therein which is lower than the initial solubility C.sub.o of the agent in the matrix. In addition, the relationship between the diffusion coefficients of the agent in the matrix D.sub.m and the portion of reinforcing means D.sub.r and the solubilities is given by the relationship: D.sub.r .multidot.C.sub.r <D.sub.m .multidot.C.sub.o. In operation the agent dissolved in the reinforcing means acts as a secondary reservoir improving the release characteristics of the system. Specific embodiments of the invention are particularly adapted for scrotal and labial delivery of drugs such as testosterone and progesterone.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.