Tricyclic derivatives of substituted pyrimidines

US4704392A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• Julien P. H. Verheyden · Los Altos, US
• John C. Martin · Los Alamos, US
• G. V. Bindu Madhavan · Monroeville, US
• Daniel P. C. McGee · Big Bear Lake, US
• Ernest J. Prisbe · Los Altos, US

Key dates

• Filing date: Apr 14, 1986
• Grant date: Nov 3, 1987
• Expiry date: Apr 14, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds useful as antiviral agents are depicted in the formula: ##STR1## wherein: X is oxygen or NH, Y is hydrogen, iodo, fluoro, methyl or trifluoromethyl, Z is hydrogen or fluoro and Z' is fluoro; and the wavy line indicates that the group may be above or below the plane of the ring; and the pharmaceutically acceptable acid addition salts thereof.