1,3-dioxan-4-ylalkenoic acids
US4704399A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Nov 9, 1984 |
| Grant date | Nov 3, 1987 |
| Priority date | — |
| Expiry date | Nov 9, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D319/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention concerns novel 1,3-dioxan-4-yl-alkenoic and alkanoic acids of formula I wherein Ra is (1-6C)alkyl, halogeno-(1-6C)alkyl, Rb is hydrogen or as Ra, or Ra and Rb together form (2-5C)polymethylene or (2-4C)oxypolymethylene, n is 2, 3 or 4, A is vinylene or ethylene, benzene ring B optionally bears a single substituent and the substituents at positions 4 and 5 of the dioxane ring have trans-relative stereochemistry; together with pharmaceutically acceptable salts, (1-6C)-alkyl esters and (1-6C)alkanesulphonamides thereof. The compounds of formula I are antagonists of thromboxane A.sub.2 and are of value in treating a variety of disease conditions. The invention also provides processes for the manufacture of, and pharmaceutical compostions of, the compounds of formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.