Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivative useful as PAF antagonist
US4704462A · kind A · utility
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Key dates
| Filing date | Aug 22, 1985 |
| Grant date | Nov 3, 1987 |
| Priority date | — |
| Expiry date | Aug 22, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/83
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Substituted 2,3,3a,6-tetrahydro-6-oxobenzofuran derivatives have been prepared. These neolignans are found to have potent and specific PAF (Platelet-Activating-Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by PAF, for example, pain, fever, inflammation, cardiovascular disorder, asthma, lung edema, allergic disorders, skin diseases, psoriasis, toxic shock syndrome and adult respiratory distress syndrome.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.