Cationic oligopeptides having microbicidal activity

US4705777A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Robert I. Lehrer · Santa Monica, US
• Michael E. Selsted · Los Angeles, US
• Tomas Ganz · Los Angeles, US

Key dates

• Filing date: Jun 28, 1985
• Grant date: Nov 10, 1987
• Expiry date: Jun 28, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/19
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel microbicidal compositions are provided which find use as preservatives, disinfectants, antigens and the like. Particularly, cationic oligopeptides of up to about thirty-five amino acids are provided having amino acid sequences substantially comparable to the amino acid sequences of cationic oligopeptides produced by macrophage. A conserved framework structure is provided.