C-glycosidic adriamycin analogs
US4705850A · kind A · utility
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3References
17Claims
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Assignee
Inventors
Key dates
| Filing date | Nov 23, 1984 |
| Grant date | Nov 10, 1987 |
| Priority date | — |
| Expiry date | Nov 23, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H15/244
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein is a new procedure for preparing the C.1-2,4-pentadienyl derivatives of 2-deoxyhexopyranoses, as well as a new procedure for allylation of daunosamine. These methods are particularly useful for the preparation of intermediates in the synthesis of adriamycin C-glycosidic analogs which are useful anti-tumor agents. These methods provide the first enabling disclosure of methods to prepare these desired adriamycin and anthrocyclinone C-glycosidic analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.