Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor

US4707357A · kind A · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• John B. Dame · Gainesville, US
• Jackie Williams · Universal City, US
• Thomas F. McCutchan · Silver Spring, US
• Imogene Schneider · Gaithersburg, US

Key dates

• Filing date: Jun 26, 1984
• Grant date: Nov 17, 1987
• Expiry date: Jun 26, 2004

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/29
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An immunologically active substantially pure peptide capable of inducing in human an immune response which is cross reactive with and protective against infection by a malaria parasite, wherein the peptide contains at least 2 consecutive repeats of a sequence Asn-X-Y-Pro wherein X is Ala or Val and Y is Asn or Asp or a sequence of the formula Thr-Glu-Trp-Z-Pro-Cys-Ser-Val-Thr-Cys-Gly-Asn-Gly wherein Z is Ser or Thr or the formula Lys-Pro-S-T-S-Lys-Leu-Lys-Gln-Pro-U-V-Gly-W-Pro wherein S is Lys or Asn, T is His or Glu, U is Gly or Asn, V is As or Glu, and W is Asn or Gln is disclosed along with DNA sequences and various other genetic materials useful in producing these peptides through biological methods.