Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines

US4707543A · kind A · utility

Assignee

• The United States of America as represented by the Secretary of the Army · US

Inventors

• Wendell D. Zollinger · Silver Spring, US
• John Boslego · Bethesda, US
• Ellen M. Moran · Indianapolis, US
• Brenda L. Brandt · Gaithersburg, US
• Hugh Frederick Collins · Largo, US
• Robert E. Mandrell · Sonoma, US
• Patricia Altieri · Silver Spring, US
• Sanford Berman · Silver Spring, US

Key dates

• Filing date: Sep 17, 1985
• Grant date: Nov 17, 1987
• Expiry date: Sep 17, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/825
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Process for preparing a detoxified polysaccharide-outer membrane protein complex from bacterial envelopes; the so-obtained products which are useful as vaccines against infection by the same bacteria and method for protecting animals against the same infection by administration of a pharmaceutical composition containing the detoxified polysaccharide-outer membrane protein complexes.