Oral anti-diabetic pharmaceutical forms and the preparation thereof

US4708868A · kind A · utility

Assignee

• Dr. Karl Thomae GmbH · DE

Inventors

• Rolf-Stefan Brickl
• Gottfried Schepky · Biberach, DE
• Eckhard Rupprecht · Dinkelsbühl, DE
• Andreas Greischel · Zell am Harmersbach, DE

Key dates

• Filing date: May 31, 1984
• Grant date: Nov 24, 1987
• Expiry date: May 31, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention is directed to novel galenic preparation forms for providing an oral anti-diabetic agent having an improved release of active substance and to processes for producing these preparation forms. The pharmaceutical compositions are characterized in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the anti-diabetically active substance in a quantity such that the active substance is made soluble, and then a solubilizing agent is added. The solution is applied to a water-insoluble carrier, the solvent is evaporated, and the residue is further processed to yield the various preparation forms.