(2-5')-Oligo (3'-deoxyadenylate) and derivatives thereof
US4708935A · kind A · utility
6Cited by
7References
6Claims
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Assignee
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Key dates
| Filing date | Mar 29, 1985 |
| Grant date | Nov 24, 1987 |
| Priority date | — |
| Expiry date | Mar 29, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P19/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
3'-deoxyadenosine 5'-triphosphate is oligomerized to form (2'-5')-oligo (3'-deoxyadenylate) by incubation with adenosine triphosphate: (2'-5')-oligo adenosine adenyl transferase, in the presence of an inert support carrying a double straded polynucleotide. The (2'-5')-oligo (3'-deoxyadenylate) is digested with a suitable phosphatase to remove the terminal phosphate groups. The thus produced corresponding 3'-deoxyadenosine compound is an anti-viral material effective against Herpes Simplex infection and effective in inhibiting the transformation of cells infected with Epstein Barr virus.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.