Bicyclic spirosulfonimides with psychotropic activity
US4709027A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 25, 1986 |
| Grant date | Nov 24, 1987 |
| Priority date | — |
| Expiry date | Jun 25, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are disclosed compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or lower alkyl, or R.sup.1 and R.sup.2 taken together represent ##STR2## A is O or NR.sup.3 ; B is --(CH.sub.2).sub.n --, ##STR3## R.sup.3 is hydrogen or lower alkyl; R.sup.4 is hydrogen, lower alkyl, aryl of 6-12 carbon atoms or halo; PA0 R.sup.5 is unsubstituted or substituted phenyl, 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl or 3-pyridazinyl, where the substituents are selected from the group lower alkyl, lower alkoxy, halo, cyano, nitro and trifluoromethyl; PA0 Z is --(CH.sub.2).sub.n -- or vinylene; PA0 X is lower alkylene, vinylene or O; PA0 m is 2-5; PA0 n is 1-3; PA0 o is 1-5; and the pharmaceutically acceptable salts thereof and their use as antipsychotic/anxiolytic agents having a low liability for extrapyramidal side effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.