Patent · US Expired

Process and reagent for the determination of fibrin monomer in plasma

US4710459A · kind A · utility

6Cited by

2References

5Claims

0Family size

Assignee

Boehringer Mannheim GmbH · DE

Inventors

Knut Bartl · Weilheim in Oberbayern, DE
Helmut Lill · Wielenbach, DE

Key dates

Filing date	Aug 21, 1985
Grant date	Dec 1, 1987
Priority date	—
Expiry date	Aug 21, 2005

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S435/81
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides a process for the determination of fibrin monomer in plasma, wherein a plasma sample containing fibrin monomer and freed from plasmin inhibitors is incubated in buffered solution with tissue plasminogen activator (EPA), plasminogen and a chromogenic plasmin substrate and the color formed is measured as a measure of the amount of fibrin monomer. The present invention also provides a reagent for the determination of fibrin monomer in plasma, wherein it contains plasminogen, tissue plasminogen activator (EPA), chromogenic plasmin substrate and buffer (pH 7.0 to 9.0).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.