N-glycosylated carboxylic acid derivatives as agents for combating rheumatic diseases

US4710491A · kind A · utility

Assignee

• Troponwerke GmbH & Co. KG · DE

Inventors

• Oswald Lockhoff · Cologne, DE
• Peter Stadler · Haan, DE
• Hans-Georg Opitz · Weinheim, DE
• Harald Horstmann
• Bodo Junge · Wuppertal, DE
• Bernhard Pelster · Sankt Augustin, DE

Key dates

• Filing date: Dec 14, 1984
• Grant date: Dec 1, 1987
• Expiry date: Dec 14, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method of combating rheumatic diseases which comprises administering to a patient afflicted therewith an amount effective to combat such disease of a compound of the formula ##STR1## in which Z is a glycosyl radical bonded via the anomeric carbon atom, PA0 R.sub.1 is hydrogen or an optionally substituted hydrocarbon radical with up to 30 C atoms, which hydrocarbon radical is optionally interrupted by O, N or S, and PA0 R.sub.2 is hydrogen or an alkyl or aralkyl radical with up to 30 C atoms, which is optionally interrupted by O, N or S or substituted by an oxygen-containing group or halogen, with the proviso that COR.sub.1 is not an acyl group with 1-5 C atoms if R.sub.2 is alkyl with 10-20 C atoms.