Asymmetric heterocyclic ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acids
US4710505A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 19, 1986 |
| Grant date | Dec 1, 1987 |
| Priority date | — |
| Expiry date | Feb 19, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D411/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to new asymmetric heterocyclic ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acids of the formula: ##STR1## wherein R.sub.1 is a C.sub.1 -C.sub.4 -alkyl group; X and Y, which are identical or different, each represent O or S, at least one of the symbols X and Y being different from S; n is an integer equal to 1 or 2; and R.sub.2 and R.sub.3, which are identical or different, each represent H, CH.sub.3, CF.sub.3, C.sub.6 H.sub.5 or halogenophenyl, it being possible for R.sub.2 and R.sub.3, taken together, to form a 5-membered to 7-membered spirocycloaliphatic group with the C atom of the heterocyclic group to which they are bonded; and their optical iomers and diastereoisomers. These new derivatives are useful as pharmaceuticals, in particular as vasodilators.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.