Antihypertensive thienopyridines
US4710506A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 13, 1986 |
| Grant date | Dec 1, 1987 |
| Priority date | — |
| Expiry date | Jun 13, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/36
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel thienopyridones with antihypertensive activity have the formula I, ##STR1## wherein the ring A represents an optionally substituted thiophene ring; m is 0 or 1; n is 0, 1 or 2; R is lower alkyl and R.sub.1 is lower alkyl. The fused thieno-ring may carry one or two substituents. Formula I encompasses thieno[3,2-b]pyridones, thieno[3,4-b]pyridones and thieno[2,3-b]pyridones. Processes for preparing the novel thienopyridones and pharmaceutical compositions containing them are described. Pharmaceutically acceptable acid addition salts of the compounds of formula I are also described. The thienopyridones of formula I are antihypertensive agents and are also indicated for use in treating heart failure and ischaemic heart disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.