Peptido-mimetic substances with hypotensive action

US4713368A · kind A · utility

Assignees

• Eniricerche S.p.A. · IT
• Polifarma S.p.A. · IT

Inventors

• Alessandro Sisto · Roma, IT
• Antonio S. Verdini · Monterotondo, IT
• Antonino Virdia · Roma, IT
• Giovanna De Luca · Roma, IT
• Giovanni Di Stazio · Roma, IT
• Vincenzo Politi · Roma, IT

Key dates

• Filing date: Jul 17, 1986
• Grant date: Dec 15, 1987
• Expiry date: Jul 17, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Peptido-mimetic compounds of hypotensive action definable by the general formula: ##STR1## in which: X represents the pyroglutamic acid residue or a ##STR2## residue where R.sub.2 represents a hydrogen atom, an alkyloxycarbonyl, an arylalkyloxycarbonyl or an acyl group with from 1 to 7 carbon atoms in the linear chain, PA0 R.sub.1 represents the aromatic residue of L-phenylalanine, L-tyrosine or L-tryptophan, and PA0 Z represents a hydroxyl, hydroxyalkyl, amino or alkylamino group, and their salts and alkyl amides or esters.