Oligopeptidylargininol derivatives and their homologs, a process for their preparation, their use and agents containing them
US4713369A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Feb 14, 1986 |
| Grant date | Dec 15, 1987 |
| Priority date | — |
| Expiry date | Feb 14, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to new peptidylargininol derivatives and their homologs of the general formula EQU X-D-Phe-Pro-A-Y.(HB).sub.n, PA0 X being a hydrogen atom or a known protective group customary in peptide chemistry, PA0 D-Phe being D-phenylalanine, PA0 Pro being L-proline, PA0 A being a .omega.-guanidiano-.beta.-aminoalkanol residue of the formula --NHCH (CH.sub.2).sub.m NHC(NH)NH.sub.2 CH.sub.2 O, with m being 2 to 5, preferably an argininol residue or a homoargininol residue, PA0 Y being a hydrogen atom or an ester-forming group, PA0 B being an acid residue, and PA0 n being 0, 1 or 2, and to a process for the preparation of these compounds, to pharmaceutical agents containing these compounds, and to the use of these agents as thrombin inhibitors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.