Anthracycline derivatives and their use as cytostatics

US4713371A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Werner Aretz · Königstein, DE
• Hans G. Berscheid · Schwalbach am Taunus, DE
• Gerhard Huber · Frankenhofen, DE
• Hans-Wolfram Fehlhaber · Idstein, DE
• Hans Kraemer · Marburg, DE
• Hans-Harald Sedlacek · Marburg, DE
• Bimal N. Ganguli · Yellandu, IN
• Ratan S. Sood · Yellandu, IN
• Julia Gandhi · Yellandu, IN
• Gauknapalli C. Reddy · Yellandu, IN

Key dates

• Filing date: Feb 3, 1986
• Grant date: Dec 15, 1987
• Expiry date: Feb 3, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P19/56
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to the micro-organism Streptomyces purpurascens (DSM 2658), its mutants and variants, a process for the preparation of anthracycline derivatives by fermentation of these cultures and to the anthracycline derivatives themselves. The new compounds are distinguished by antibacterial activity and, in addition, they act against various types of tumors.