2-chloropentostatin compound having adenosine diaminase inhibitory activity
US4713372A · kind A · utility
8Cited by
5References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 8, 1985 |
| Grant date | Dec 15, 1987 |
| Priority date | — |
| Expiry date | Nov 8, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/01
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
2'-Chloropentostatin is a potent inhibitor of the enzyme adenosine deaminase and possesses utility as an agent for potentiating the activity of antiviral agents for the treatment of DNA viruses which agents contain an adenine moiety, such as 9-(beta-D-arabinosyl)adenine. A pure strain of actinomycete, designated ATCC 39365 which is capable of producing 2'-chloropentostatin, a method of producing 2'-chloropentostatin by aerobic fermentation, and pharmaceutical compositions including 2'-chloropentostatin are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.