Patent · US Expired

Renin inhibitors and treatments using them

US4713445A · kind A · utility

13Cited by
2References
35Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 17, 1984
Grant dateDec 15, 1987
Priority date—
Expiry dateAug 17, 2004

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10S530/86
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

Renin-inhibiting analogues of formula ##STR1## where X and W are terminal groups optionally with further amino acyl residues; D, E, B and Z (of which any one or except with `reduced` analogues any two may be absent) are aromatic, lipophilic or in the case of E aromatic lipophilic or basic amino acid or amino acid analogue residues; and A is an analogue of a lipophilic or aromatic dipeptide residue wherein the peptide link is replaced by a one- to four-atom carbon or carbon-nitrogen link which as such or in hydrated form is an unhydrolysable tetrahedral analogue of the transition state ##STR2## of peptide bond hydrolysis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.