Viscoelastic collagen solution for ophthalmic use and method of preparation
US4713446A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 6, 1986 |
| Grant date | Dec 15, 1987 |
| Priority date | — |
| Expiry date | Aug 6, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S128/08
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Chemically-modified collagen is prepared by reacting native collagen with a di or tri-carboxylic acid halide, di or tri-sulfonyl halide, di or tri-anhydride, or di or tri-reactive active ester coupling agent. The reaction is done in a controlled manner so that the degree of cross-linking is limited. Any remaining lysine epsilon amino groups present in the coupled collagen product may be converted to carboxyamido or sulfonamido groups by acid halide, anhydride, sulfonyl halide or active ester amine-modifying agents. The resultant product when dissolved in a physiological buffer provides a viscoelastic solution having therapeutic application in a variety of surgical procedures, particularly in ophthalmic surgery. This viscoelastic solution "melts," i.e., exhibits a dramatic loss of viscosity, when subjected to temperatures of between 32.degree. and 48.degree. C.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.