N-(2,10-dioxa-tricyclo-[5,3,1,0.sup.3,8 ]-undecane-5-yl)-tryptamine derivatives and medical compositions thereof

US4714709A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Peter W. Thies · Hannover, DE
• Samuel David · Dorval, CA
• Ulrich Kuehl · Hannover, DE
• Gerd Buschmann · Velbert, DE
• Peter Flecker · Bad Vilbel, DE

Key dates

• Filing date: Sep 24, 1984
• Grant date: Dec 22, 1987
• Expiry date: Sep 24, 2004

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

N-(2,10-dioxa-tricyclo-[5,3,1,0.sup.3,8 ]-undecane-5-yl)-tryptamine compounds corresponding to the formula ##STR1## with blood-pressure lowering effects, a method of producing such compounds and pharmaceutical compositions incorporating such compounds, wherein R.sub.1 is hydrogen, a benzyl or lower alkyl group; R.sub.2 is a lower alkyl or lower alkanoyl group; R.sub.3 is hydrogen or a lower alkyl group; R.sub.4 is hydrogen, benzyloxy, hydroxy or a lower alkoxy group; R.sub.5 is hydrogen, benzyloxy, hydroxy or a lower alkoxy group; and A and B either are both hydrogen or together represent a bond between their respective carbons.