ARG.sup.7 -ARG.sup.8 -vasopressin antagonists
US4717715A · kind A · utility
3Cited by
3References
16Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 23, 1986 |
| Grant date | Jan 5, 1988 |
| Priority date | — |
| Expiry date | Jun 23, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/15
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Vasopressin antagonists which have a dipeptide side chain comprised of two basic amino acids demonstrate potent V.sub.1 and V.sub.2 -antagonist activity. A species of the invention, which is prepared by conventional peptide sequencing, is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylene propionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-arginine-9-desglycine]- vasopressin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.