Esters of pyridine-2,4- and 2,5-dicarboxylic acid as medicaments for the inhibition of proline hydroxylase and lysine hydroxylase

US4717727A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Volkmar Gunzler · Marburg, DE
• Hartmut Hanauske-Abel · Edgewater, US
• Jurgen Mohr · Grünstadt, DE
• Georg Tschank · Frankfurt am Main, DE
• Kari Kivirikko · Oulu, FI
• Kari Majamaa · Rancho Palos Verdes, US
• Dietrich Brocks · Wiesbaden, DE

Key dates

• Filing date: Aug 29, 1985
• Grant date: Jan 5, 1988
• Expiry date: Aug 29, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/80
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Esters of pyridine-2,4- and -2,5-dicarboxylic acid act as inhibitors of proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants, in particular for the treatment of disturbances of the metabolism of collagen and collagen-like substances and of the biosynthesis of Cl.sub.q.