3-vinyl and 3-thyinyl-beta-carbolines, and their use as benzodiazepine receptor antagonists or agonists

US4719210A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Dieter Seidelmann · Berlin, DE
• Andreas Huth · Berlin, DE
• Ralph Schmiechen · Berlin, DE
• Rudolf Wiechert · Berlin, DE
• Herbert Schneider · Berlin, DE
• David N. Stephens · Berlin, DE

Key dates

• Filing date: Oct 6, 1986
• Grant date: Jan 12, 1988
• Expiry date: Oct 6, 2006

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## wherein R.sup.1 is hydrogen or a protecting group, PA1 R.sup.2 is --CH.dbd.CR.sub.2.sup.4 or --C.tbd.CR.sup.4, PA1 R.sup.4 is hydrogen or halogen, PA1 R.sup.3 is hydrogen, lower alkyl or lower alkoxyalkyl, PA1 R.sup.A is, inter alia, hydrogen, OR.sup.7, lower alkyl, which optionally is substituted with aryl, lower alkoxy or NR5R6, PA1 R.sup.5 and R.sup.6 can be the same or different and in each case is hydrogen, lower alkyl or together with the nitrogen atom a 5-6 member ring, which can contain another heteroatom, PA1 R.sup.7 is lower alkyl, optionally substituted aryl or aralkyl, and PA1 each compound can contain one or more R.sup.A radicals which are not hydrogen, have valuable pharmacological properties.