Phenyl-azacycloalkanes and use thereof in treatment of central nervous system disorders

US4719219A · kind A · utility

Assignee

• Per A. E. Carlsson · SE

Inventors

• Folke L. Arvidsson · Uppsala, SE
• Per A. E. Carlsson · Göteborg, SE
• Uli A. Hacksell · Uppsala, SE
• John S. M. Hjorth · Göteborg, SE
• Per L. Lindberg · Mölndal, SE
• John L. G. Nilsson · Tullinge, SE
• Domingo Sanchez · Floda, SE
• Nils U. E. Svensson · Brunna, SE
• Hakan V. Wikstrom · Mölndal, SE

Key dates

• Filing date: Oct 1, 1984
• Grant date: Jan 12, 1988
• Expiry date: Oct 1, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/22
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compound of the formula ##STR1## wherein n is 1 or 2, Y is OH, R.sup.1 COO--, R.sup.2 R.sup.3 NCOO-- or R.sup.4 O whereby R.sup.1 is an alkyl group, or a possibly substituted phenyl group, R.sup.2 is an alkyl, phenethyl, or benzyl or phenyl group, R.sup.3 is H or an alkyl group and R.sup.4 is an allyl or benzyl group, and R is an alkyl, hydroxyalkyl, dimethylaminoalkyl or methylthioalkyl group or alkenyl group, processes for their preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.