Glycopeptides, process for their preparation and their use

US4719289A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Cenek Kolar · Marburg, DE
• Friedrich-Robert Seiler · Marburg, DE
• Ursula Knodler · Allendorf (Lumda), DE

Key dates

• Filing date: Sep 16, 1985
• Grant date: Jan 12, 1988
• Expiry date: Sep 16, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Compounds of the general formula I, II or III EQU R.sup.1 --A.sup.1 --T--NH--R.sup.2 --COR.sup.3 I EQU R.sup.1 --A.sup.1 --T--A.sup.2 --NH--R.sup.2 --COR.sup.3 II EQU R.sup.1 --A.sup.1 --T--A.sup.2 --A.sup.3 --T--A.sup.4 --NH--R.sup.2 --COR.sup.3 III are described, in which PA0 R.sup.1 is a hydrogen atom, an alkoxycarbonyl or arylalkoxycarbonyl group conventionally used for protecting amino groups, or CH.sub.3 --(CH.sub.2).sub.m --CO, in which m=0-16, PA0 R.sup.2 is --(CH.sub.2).sub.n -- or --(CHOH).sub.n --, in which n=1-10, PA0 R.sup.3 is a hydroxyl group, an 0-alkyl or 0-arylalkyl protecting group, a group which activates carboxyl groups, a cephalin radical, an amino acid radical of oligopeptides, polypeptides or proteins which carries NH groups, or a carrier, A.sup.1, A.sup.2, A.sup.3 or A.sup.4 is a bonding dash or an amino acid radical present in glycophorin A, such as Ala, Val, Leu, Ile, Ser, Pro, Glu or Arg, in which, if appropriate, the reactive groups not forming part of the peptide bond are protected by protecting groups, and the radical T is ##STR1## in which R.sup.4 denotes a hydrogen atom or an acyl protecting group, PA0 R.sup.5 denotes a hydrogen atom, an acyl protec…