Fluoralkylatedcarbapenem derivatives

US4720491A · kind A · utility

Assignee

• Sandoz AG · CH

Inventors

• Ching Pong Mak · Shanghai, CN
• Hans Fliri · Wien, AT

Key dates

• Filing date: Oct 30, 1985
• Grant date: Jan 19, 1988
• Expiry date: Oct 30, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## wherein, R.sub.1 represents hydrogen or methyl, PA0 R.sub.2 represents hydrogen or lower alkyl, lower alkenyl, lower alkynyl or cycloalkyl each of which may be unsubstituted or mono- or poly-substituted by amino, mono- or di(lower)-alkylamino, lower acylamino, carboxy, lower alkoxycarbonyl or carbamoyl; a group of formula IIc EQU (CH.sub.2).sub.p --R.sub.5 IIc PA0 wherein R.sub.5 represents phenyl or a 5- or 6-membered saturated or unsaturated heterocycle containing one or more heteroatoms selected from O, S and/or N and which may be unsubstituted or mono- or poly-substituted by fluoro, chloro, bromo, amino, mono- or di-(lower)-alkylamino, hydroxy, lower alkoxy, mercapto, alkylthio, phenylthio, sulfamoyl, guanidino, nitro, cyano, lower acylamino, carboxy, alkoxycarbonyl or carbamoyl and p is 0, 1, 2 or 3; or a group of formula ##STR2## wherein R.sub.6, R.sub.7 and R.sub.8 may be the same or different and each represents hydrogen or lower alkyl or R.sub.6 and R.sub.8 and/or R.sub.7 and one of the CH.sub.2 groups may be joined to form a ring as may R.sub.7 and R.sub.8 in formula II and R.sub.6 and R.sub.7 in IIa and IIb, which rings may be unsubstitute…