Benzo[ij]quinolizine-2-carboxylic acids useful for treating bacterial infection
US4720495A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 20, 1986 |
| Grant date | Jan 19, 1988 |
| Priority date | — |
| Expiry date | May 20, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D455/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Benzo[ij]quinolizine-2-carboxylic acid derivatives of the general formula [I] and the salts, and their hydrates are provided: ##STR1## wherein A is a methylene group and B is a carbonyl group when A and B are linked by a single bond, or A and B unite together to form a vinylene group when A and B are linked by a double bond, R.sup.1 is a hydrogen atom, a C.sub.1-3 alkyl group or a 2-hydroxyethyl group, R.sup.2 and R.sup.3 are hydrogen atoms, methyl groups or ethyl groups and may be identical to or different from each other, R.sup.3 may be attached to the same carbon atom as R.sup.2, R.sup.4 is a methyl or ethyl group, and X is a halogen atom. The benzo[ij]quinolizine-2-carboxylic acid derivatives and the salts, and their hydrates have good adsorbability from the digestive tract into the circulating blood and exhibit excellent and long-lasting antibacterial activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.