Substituted 3,4-dihydroxy-phenylethylamino compounds

US4720586A · kind A · utility

Assignee

• Fisons plc · GB

Inventors

• John Dixon · Hudson, US
• Francis Ince · Loughborough, GB

Key dates

• Filing date: Oct 18, 1984
• Grant date: Jan 19, 1988
• Expiry date: Oct 18, 2004

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are provided compounds of formula I, ##STR1## in which R.sub.1 represents OH, PA1 R.sub.2 and R.sub.3, which may be the same or different, each independently represent hydrogen, fluorine, chlorine, bromine, alkyl C1 to 6, nitro, nitrile, (CH.sub.2).sub.p R.sub.9 or SR.sub.9, PA1 W represents a single bond, a 1,2; 1,3; or 1,4-disubstituted benzene ring; a --CH.dbd.CH--group or a 1,4-cyclohexanediyl group; PA1 X respresents NH, O, S, SO.sub.2, CO, CH.sub.2, CONH or --COO; PA1 Y represents (CH.sub.2)q, CO, CS, SO.sub.2 and R.sub.20 represents hydrogen, PA1 or Y represents CR.sub.15 R.sub.16 CR.sub.17 R.sub.18, wherein the carbon atom bearing R.sub.15 and R.sub.16 is adjacent to X and in which PA1 R.sub.15 and R.sub.18, together with the carbon atom to which they are attached form a carbonyl group, and R.sub.15, R.sub.16 and R.sub.20 each represent hydrogen, or PA1 R.sub.15 and R.sub.20 together form a chain --CH.sub.2 --, and R.sub.16, R.sub.17 and R.sub.18 each represent hydrogen, or PA1 R.sub.15, R.sub.16, R.sub.17 and R.sub.18 each independently represent hydrogen or alkyl C1 to 6 and R.sub.20 represents hydrogen; PA1 Z represents a single bond, NR.sub.19, CH.sub.2, O, CO, S …