Arg-arg-arg-vasopressin antagonists
US4724229A · kind A · utility
32Cited by
4References
30Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 30, 1986 |
| Grant date | Feb 9, 1988 |
| Priority date | — |
| Expiry date | Sep 30, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/15
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Vasopressin antagonists which have a tripeptide side chain comprised of three basic amino acids, such as arginine, lysine or ornithine, demonstrate potent V.sub.1 and V.sub.2 -antagonist activity. A species of the invention, which is prepared by conventional peptide sequencing, is [1-(.beta.-mercapto-.beta.,.beta.-cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-arginine-9-arginine]-va sopression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.