5,11-dihydro-6H-pyrido(2,3-B)(1,4)benzodiazepin-6-ones substituted in the 11-position, processes for preparing them and pharmaceutical compositions containing these compounds

US4724236A · kind A · utility

Assignee

• Karl Thomae GmbH · DE

Inventors

• Wolfgang Eberlein · Biberach, DE
• Gunter Trummlitz · Warthausen, DE
• Wolfhard Engel
• Gerhard Mihm · Biberach, DE
• Rudolf Hammer · Ingelheim am Rhein, DE
• Norbert Mayer · Gersthofen, DE
• Antonio Giachetti · Marsala, IT
• Adriaan De Jonge · Driebergen-Rijsenburg, NL

Key dates

• Filing date: Dec 19, 1986
• Grant date: Feb 9, 1988
• Expiry date: Dec 19, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of general formula I are described, ##STR1## wherein X represents the group .dbd.CHR, .dbd.NR or an oxygen atom and PA0 A represents the groups --NR.sup.1 R.sup.2, wherein R.sup.1 and R.sup.2 represent alkyl, cycloalkyl or phenylalkyl groups, n represents the number 0, 1 or 2, R.sup.3 represents a hydrogen atom, a hydroxy or alkyl group or a group --(CH.sub.2).sub.n --N--R.sup.5 R.sup.6 (R.sup.5 and R.sup.6 being lower alkyl groups) and R.sup.4 is an alkyl or phenylalkyl group; two processes for preparing these compounds and the salts thereof are also described. The compounds have favourable effects on heart rate and can be used as vagal pacemakers for treating bradycardia and bradyarrhythmia in human and veterinary medicine. Some of these compounds also have very good antithrombotic effects.