Method of relieving pain and inflammatory conditions employing substituted salicylamides
US4725590A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Sep 10, 1985 |
| Grant date | Feb 16, 1988 |
| Priority date | — |
| Expiry date | Sep 10, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/41
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A topically and systemically administered anti-inflammatory composition for human and for veterinary consumption which comprises compounds of the general formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are defined hydrocarbon attachments and Y is --OH or a phenolic ester group derived from the reaction of such --OH group with a carboxylic acid halide or anhyride. In typical compounds covered by said general formula PA0 (a) R.sub.1 is H, R.sub.2 is 5,n-octanoyl, Y is hydroxy and R.sub.3 is p-trifluoromethylphenyl; PA0 (b) R.sub.1 is H, R.sub.2 is 5,n-decanoyl, Y is hydroxy and R.sub.3 is benzothiazol-2-yl and PA0 (c) R.sub.1 is H, R.sub.2 is 5,n-decanoyl, Y is acryloyloxy and R.sub.3 is p-nitrophenyl. The resulting compositions take the form of ointments, solid sticks, tablets, capsules, injectable solutions and suspensions, ear drops, eye drops, nose drops, douches, suppositories, enemas, liniments, gels, lotions, shampoos, soaps, creams, solutions, aerosols, pads, plasters, bandages, dressings and catamenial and non-cateminal tampons. The compositions are useful in relieving pain or inflammation as well as microbial infections in mammals when applied topically to the skin o…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.