2-benzyl-4-(4-pyridyl)thiazoles and derivatives thereof as immunoregulants and compositions

US4725606A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• David A. Boulton · Tinton Falls, US
• Vernon L. Moore · Scotch Plains, US
• Ihor E. Kopka · Hampton, US
• Arsenio A. Pessolano · Colonia, US

Key dates

• Filing date: Aug 21, 1986
• Grant date: Feb 16, 1988
• Expiry date: Aug 21, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D213/65
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

2-Benzyl-4-(4-pyridyl)thiazoles and derivatives thereof have been made from converting a benzyl cyanide to the corresponding thioamide followed by condensation with a 4-bromoacetylpyridine. The thiazole derivatives are found to be effective immunoregulants.