Mycophenolic acid derivatives in the treatment of rheumatoid arthritis
US4725622A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 1986 |
| Grant date | Feb 16, 1988 |
| Priority date | — |
| Expiry date | Jan 23, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/88
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method of treating rheumatoid arthritis which method comprises administering to a mammal in need of such treatment a therapeutically effective amount of a compound of the formula: ##STR1## and the pharmaceutically acceptable salts thereof, wherein: PA0 A is oxygen or sulfur; PA0 R.sup.1 is selected from the group consisting of H, ##STR2## in which Y is oxygen or sulfur: PA0 R.sup.2 is alkyl, haloalkyl or --NR.sup.4 R.sup.5, where R.sup.4 and R.sup.5 are independently H, alkyl, haloalkyl, cycloalkyl, phenyl optionally monosubstituted with halogen, hydroxy, carboxy, chlorocarbonyl, sulfonylamino, nitro, cyano, phenyl, alkyl, acyl, alkoxycarbonyl, acylamino, dialkylamino or dialkylaminoethoxycarbonyl, phenyl optionally disubstituted with hydroxy, carboxy, nitro or alkyl, or benzyl optionally substituted with dialkylamino; PA0 n is an integer from 0-6; PA0 R.sup.3 is H alkyl or a pharmaceutically acceptable cation; PA0 Q and R are independently H or --CO.sub.2 R.sup.3 ; and Z is selected from the group consisting of ##STR3## in which X is oxygen or sulfur, PA0 R.sup.7 is H, alkyl, alkenyl, cycloalkyl, optionally substituted phenyl, optionally substituted benzyl or a pharmaceutically …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.