Preparation of coated granular ibuprofen microsphere
US4726966A · kind A · utility
15Cited by
3References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 25, 1986 |
| Grant date | Feb 23, 1988 |
| Priority date | — |
| Expiry date | Nov 25, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/19
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention provides a simple method for preparing granular ibuprofen microsphere whose surface is coated with acrylic acid resin. By this method granulation of ibuprofen and coating of its surface can be simultaneously accomplished. Namely, the method of preparation includes the steps of: (a) dissolving ibuprofen with acrylic acid resin into lower aliphatic alcohol, acetone, methylene chloride or N,N-dimethylformamide; and (b) depositing coated granular ibuprofen microsphere by mixing the solution of step (a) with water and by stirring the mixed solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.