1-substituted derivatives of 6-fluoro-7-(pyrrol-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, their preparation and their application as drugs
US4727080A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Dec 9, 1985 |
| Grant date | Feb 23, 1988 |
| Priority date | — |
| Expiry date | Dec 9, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to new 1-substituted derivatives of 6-fluoro-7-(pyrrol-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, their preparation and their application as drugs. The 1-substituted derivatives of 6-fluoro-7-(pyrrol-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid according to the invention correspond to the general formula I: ##STR1## in which: R represents a methyl radical, a 2-hydroxyethyl radical, a vinyl radical, a cyclopropylmethyl radical, a propyl radical, a cyclopropyl radical, a 2-fluoroethyl radical, a methylamino radical or an ethylamino radical, as well as their physiologically acceptable alkali metal or alkaline earth metal salts. They are useful as antimicrobial agents, in particular as antibacterial and fungistatic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.