Patent · US Expired

Optically active 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinolinium acetates

US4727147A · kind A · utility

7Cited by

0References

4Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Willi Wintermeyer · Seeheim-Jugenheim, DE
Fritz Reiff · Seeheim-Jugenheim, DE
Hans Muller · Kirkland, US
Josef Conti · Schaffhausen, CH

Key dates

Filing date	Oct 3, 1985
Grant date	Feb 23, 1988
Priority date	—
Expiry date	Oct 3, 2005

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D217/20
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Racemic 1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline can be resolved by seeding the supersaturated solution of racemic 1-(4-methoxybenzyl)-octahydroisoquinolinium acetate with its enantiomeric forms and crystallizing the optically active acetate corresponding to the configuration of the seed crystals. The continuous form of the process permits obtaining the two enantiomers together.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.