Contrast agents for NMR imaging
US4728575A · kind A · utility
127Cited by
10References
25Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 10, 1985 |
| Grant date | Mar 1, 1988 |
| Priority date | — |
| Expiry date | Apr 10, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/1812
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An agent for contrast enhancement in nuclear magnetic resonance imaging is disclosed. Micellular particles such as phospholipid vesicles are associated with or enclose a paramagnetic material. The particles may be formulated with an agent, such as cholestrol, to promote vesicle stability and water exchange across the vesicle bilayer. The vesicles may or may not have antibodies or other cell recognition targeting agents attached to the surface to provide specific targeting. The vesicles provide enhanced target specificity, reduced burden of toxic contrast material and amplified contrast enhancement.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.