Purifications of B-cell inducing factor (BIF) and B-cell growth factor (BGF)
US4730036A · kind A · utility
10Cited by
5References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 3, 1984 |
| Grant date | Mar 8, 1988 |
| Priority date | — |
| Expiry date | Jan 3, 2004 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/5409
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Highly purified T cell replacing factor (TRF or BIF) essentially free of IL-2 and Interferon activities is obtained in the invention. BIF is useful for treatment of immunoregulatory disorders and/or stimulation of production of immunoglobulins. A method for production of BIF and BGF is described. B cell lines for BIF assays are described as well as an assay for B cell receptor variants and a method for obtaining B cell variants from a variety of source materials.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.