Cis-platinum complexes with a pentaerythritol derivative as the ligand, a process for their preparation and a pharmaceutical agent containing these compounds

US4730069A · kind A · utility

Assignee

• Behringwerke Aktiengesellschaft · DE

Inventors

• Cenek Kolar · Marburg, DE
• Hans Kraemer · Marburg, DE
• Konrad Dehmel · Marburg, DE

Key dates

• Filing date: Aug 30, 1985
• Grant date: Mar 8, 1988
• Expiry date: Aug 30, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F15/0093
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the general formulae I and II ##STR1## in which R.sup.1 and R.sup.2 independently of one another represent H--(CH.sub.2).sub.a --(O--(CH.sub.2).sub.b).sub.c --O, where a=0 to 4, b=1 to 4 and c=1 to 7, an alkoxy or arylalkoxy group with 1 to 20 carbon atoms, an alkane- or aralkanesulfonyloxy group with 1 to 7 carbon atoms or a tetrahydropyranyloxy radical, or PA0 R.sup.1 and R.sup.2 together represent an oxygen atom bonded in an ether-like manner or an acetal or ketal radical ##STR2## where R.sup.3 and R.sup.4 independently of one another represent a hydrogen atom, an alkyl group with 1 to 20 carbon atoms of a phenyl group, PA0 A.sup.1 and A.sup.2 are identical and represent a hydroxyl group, chloride, bromide, iodide, nitrate, acetate, trifluoroacetate, trifluorosulfonate or perchlorate, or PA0 A.sup.1 represents sulfate or carbonate ion and A.sup.2 represents H.sub.2 O, or PA0 A.sup.1 A.sup.2 together represent the dianion of an organic acid, such as oxalic, malonic, hydroxymalonic, ethylmalonic, succinic, maleic, aconitic, 3,6,9-trioxaundecanedioic, 1,1- or 1,2-cyclobutanedicarboxylic, phthalic, 3- or 4-carboxyphthalic or 3,4-dicarboxyphthalic acid, or PA0 A.sup.1 an…