2-(-(2,2,5,5-tetramethyl-3-pyrrolin-3-carbonyl))-amino derivatives
US4731376A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 14, 1986 |
| Grant date | Mar 15, 1988 |
| Priority date | — |
| Expiry date | Aug 14, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D207/16
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds are disclosed of the formula (I) ##STR1## wherein A.sup.1 is a valence bond or a C.sub.1 to C.sub.5 straight or branched chain alkylene group unsubstituted or substituted by hydroxy or aminocarbonyl; PA1 B is a valence bond or a double bond; PA1 R.sup.3 is hydrogen or C.sub.1 to C.sub.4 alkyl; PA1 R.sup.2 is a phenyl or phenoxy group unsubstituted or substituted by one or two C.sub.1 to C.sub.4 alkyl groups, C.sub.1 to C.sub.4 alkoxy groups, or halo substituents; or R.sup.2 is an amino group, a diphenylmethyl group, or an R.sup.4 --NH--CO-- group in which PA1 R.sup.4 is 2,6-dimethyl-phenyl; or a pharmaceutically acceptable acid addition salt thereof. The compounds possess anti-arrhythmic activity and exert little or no hypotensive side effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.