Retro-inverso hexapeptide neurotensin analogs, process for their preparation and pharmaceutical compositions containing them
US4732890A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1986 |
| Grant date | Mar 22, 1988 |
| Priority date | — |
| Expiry date | Aug 5, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/06
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Hexapeptides with vasodilating and hypotensive activity are described corresponding to the formula: ##STR1## wherein: X is a hydrogen atom or an acyl radical R.sub.3 -CO- wherein R.sub.3 is a straight or branched (C.sub.1 -C.sub.7)alkyl group, R.sub.1 and R.sub.2, each independently, represent the side-chain residue of the amino acid glycine (--H), alanine (--CH.sub.3), valine ##STR2## leucine ##STR3## or isoleucine ##STR4## Arg is the abbreviated designation for arginine, Pro is the abbreviated designation for proline, Tyr is the abbreviated designation for tyrosine, and the pharmaceutically acceptable salts, lower alkyl esters and amides thereof, a process for their preparation and the pharmaceutical compositions containing them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.