Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents

US4732978A · kind A · utility

Assignee

• Amerimas Home Products, Inc. · US

Inventors

• Anthony F. Kreft, III. · Trooper, US
• Kenneth L. Kees · Plainsboro, US
• John H. Musser · Alameda, US
• James J. Bicksler · Titusville, US
• Winifred P. Howse · Phoenixville, US

Key dates

• Filing date: Sep 12, 1986
• Grant date: Mar 22, 1988
• Expiry date: Sep 12, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/64
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are disclosed compounds having the formula ##STR1## wherein X is CR or N when n=1; or PA0 X is O, S, NR or CR when n=0; PA0 R is hydrogen or lower alkyl; PA0 Y is --CH.sub.2 --, --S--, --O-- or ##STR2## and A is ##STR3## Z is CH or N; R.sup.1 is halo or trifluoromethyl; PA0 R.sup.2 is hydrogen or halo; PA0 R.sup.3 is hydrogen or halo; with the proviso that when A is naphthyl, Y is --O-- and n=0, X is other than S; and their use in the treatment of inflammatory conditions and in the treatment of leukotriene-medicated naso-bronchial obstructive passageway conditions.