Piperazinoisothiazolones with psychotropic activity
US4732984A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 1986 |
| Grant date | Mar 22, 1988 |
| Priority date | — |
| Expiry date | Aug 5, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There are disclosed compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, lower alkyl, aryl or halo, or R.sup.1 and R.sup.2 taken together represent --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --O--, --NH--, ##STR2## where the dotted lines represent optional double bonds; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each, independently, hydrogen, lower alkyl, aryl or halo; PA0 R.sup.7 is 2-pyridinyl, 2-pyrimidinyl, 2-pyrazinyl, 3-pyridazinyl or phenyl or any of the foregoing R.sup.7 moieties substituted by lower alkyl, trifluoromethyl, cyano, nitro or halo, with the proviso that when R.sup.1 and R.sup.2 taken together represent ##STR3## then R.sup.7 is other than 2-pyridinyl, 2-pyrimidinyl or substituted pyrimidin-2-yl; PA0 Z is --(CH.sub.2).sub.n --, vinylene, --O--, or ##STR4## X is lower alkylene, vinylene, O or NH; m is 2-5; PA0 n is 0-4; PA0 o is 1-3; PA0 p is 1-4; and the pharmaceutically acceptable salts thereof, and their use as antipsychotic/anxiolytic agents having a low liability for extrapyramidal side effects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.