2-oxygen containing heteroalkoxyalkyl dihydropyridine intermediates
US4732985A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 5, 1986 |
| Grant date | Mar 22, 1988 |
| Priority date | — |
| Expiry date | Nov 5, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
1,4-Dihydropyridine anti-ischaemic and antihypertensive agent of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R is 2-chlorophenyl, 2,3-dichlorophenyl or 2-chloro-3-trifluoromethylphenyl; PA0 R.sup.1 and R.sup.2 are each independently C.sub.1 -C.sub.4 alkyl; PA0 X is O or S; PA0 R.sup.3 is H or C.sub.1 -C.sub.4 alkyl; and PA0 R.sup.4 is 1,2,4-triazol-1-ylmethyl, imidazol-1-ylmethyl, azidomethyl, 2,4,5-trimethylimidazol-1-ylmethyl, 3,4-dihydro-4-oxopyrimidin-2-ylthiomethyl, pyrimidin-2-ylthiomethyl; pyrimidin-2-ylaminomethyl, 3,4-dihydro-4-oxopyrimidin-2-ylaminomethyl, 2-aminopyrimidin-4-yloxymethyl, methoxymethyl, 2-furyl, 2-pyridylmethyl, imidazol-2-yl, hydroxymethyl, aminomethyl, 1,2,4-triazol-4-ylmethyl or 2-hydroxyethyl, and intermediates leading thereto.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.